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Harbin Institute of Technology, Building 2E, Science Park, 2 Yikuang Street, Harbin 150080
China

Tel: 86403181, 13804586349

Zip code:150001

Email: kigo@hit.edu.cn

About Us

Dr. Wu’s research interest is to understand the underlying mechanism how non-coding RNAs including miRNAs and lncRNAs regulate embryogenesis. To uncover the potential mechanims, Wu has focused on gene imprinting and epigenetics in mice since Ph. D.

 

Genomic imprinting is a genetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. In diploid organisms, somatic cells possess two copies of the genome. The expressed allele is dependent upon its parental origin. For example, the gene encoding Insulin-like growth factor 2 (IGF2/Igf2) is only expressed from the allele inherited from the father.

 

Dr. Wu has previously made parthenogenetic mice “Kaguya” and found that Igf2-H19 and Dlk1-Gtl2 are vital to the birth of mice. In addition, Dr, Wu has identified several non-coding and coding imprinted RNAs, including Meg8, AB063319 and Qpct. These non-coding RNAs were further studied to uncover their function in embryogenesis, specifically, by spatio and temporal expression by RT-PCR and ISH technology.

 

His lab is growing rapidly, in terms of funds, involving a total of 17 projects and 3.2 million yuan. The lab is equipped with cutting-edge instruments, supporting high-level molecular biology researches. In next years, the lab is planning to do a lot of work on interdisciplinary researches, such as non-coding RNA predictions, imprinting gene predictions and influences of environmental factors such as estrogen upon embryonic development. Given the new situation of rapid life science development, the lab has been prepared to develop into a lab with international influence.

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